4GB9

Potent and Highly Selective Benzimidazole Inhibitors of PI3K-delta

Summary for 4GB9

Entry DOI	10.2210/pdb4gb9/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-[1-({2-[2-(dimethylamino)-1H-benzimidazol-1-yl]-9-methyl-6-(morpholin-4-yl)-9H-purin-8-yl}methyl)piperidin-4-yl]propan-2-ol (3 entities in total)
Functional Keywords	kinase p110 gamma-isoform, kinase, lipid kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P48736
Total number of polymer chains	1
Total formula weight	111260.77
Authors	Murray, J.M. (deposition date: 2012-07-26, release date: 2012-08-22, Last modification date: 2023-09-13)
Primary citation	Murray, J.M.,Sweeney, Z.K.,Chan, B.K.,Balazs, M.,Bradley, E.,Castanedo, G.,Chabot, C.,Chantry, D.,Flagella, M.,Goldstein, D.M.,Kondru, R.,Lesnick, J.,Li, J.,Lucas, M.C.,Nonomiya, J.,Pang, J.,Price, S.,Salphati, L.,Safina, B.,Savy, P.P.,Seward, E.M.,Ultsch, M.,Sutherlin, D.P. Potent and highly selective benzimidazole inhibitors of PI3-kinase delta. J.Med.Chem., 55:7686-7695, 2012 Cited by PubMed: 22877085 DOI: 10.1021/jm300717c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.438 Å)

Structure validation