4GB9

Potent and Highly Selective Benzimidazole Inhibitors of PI3K-delta

4GB9 の概要

• エントリーDOI: 10.2210/pdb4gb9/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-[1-({2-[2-(dimethylamino)-1H-benzimidazol-1-yl]-9-methyl-6-(morpholin-4-yl)-9H-purin-8-yl}methyl)piperidin-4-yl]propan-2-ol (3 entities in total)
• 機能のキーワード: kinase p110 gamma-isoform, kinase, lipid kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P48736
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111260.77

構造登録者

Murray, J.M. (登録日: 2012-07-26, 公開日: 2012-08-22, 最終更新日: 2023-09-13)

• 主引用文献: Murray, J.M.,Sweeney, Z.K.,Chan, B.K.,Balazs, M.,Bradley, E.,Castanedo, G.,Chabot, C.,Chantry, D.,Flagella, M.,Goldstein, D.M.,Kondru, R.,Lesnick, J.,Li, J.,Lucas, M.C.,Nonomiya, J.,Pang, J.,Price, S.,Salphati, L.,Safina, B.,Savy, P.P.,Seward, E.M.,Ultsch, M.,Sutherlin, D.P.; Potent and highly selective benzimidazole inhibitors of PI3-kinase delta.; J.Med.Chem., 55:7686-7695, 2012; PubMed: 22877085; DOI: 10.1021/jm300717c

実験手法

X-RAY DIFFRACTION (2.438 Å)