4G8V

Crystal structure of Ribonuclease A in complex with 5a

Summary for 4G8V

• Entry DOI: 10.2210/pdb4g8v/pdb
• Related: 4G8Y 4G90
• Descriptor: Ribonuclease pancreatic, 1-{[1-(alpha-L-arabinofuranosyl)-1H-1,2,3-triazol-4-yl]methyl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidine (3 entities in total)
• Functional Keywords: nuclease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• Total number of polymer chains: 2
• Total formula weight: 27741.93

Authors

Chatzileontiadou, D.S.M.,Kantsadi, A.L.,Leonidas, D.D. (deposition date: 2012-07-23, release date: 2012-11-21, Last modification date: 2023-09-13)

• Primary citation: Parmenopoulou, V.,Chatzileontiadou, D.S.,Manta, S.,Bougiatioti, S.,Maragozidis, P.,Gkaragkouni, D.N.,Kaffesaki, E.,Kantsadi, A.L.,Skamnaki, V.T.,Zographos, S.E.,Zounpoulakis, P.,Balatsos, N.A.,Komiotis, D.,Leonidas, D.D.; Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.; Bioorg.Med.Chem., 20:7184-7193, 2012; PubMed: 23122937; DOI: 10.1016/j.bmc.2012.09.067

Experimental method

X-RAY DIFFRACTION (1.7 Å)