4G8V

Crystal structure of Ribonuclease A in complex with 5a

4G8V の概要

• エントリーDOI: 10.2210/pdb4g8v/pdb
• 関連するPDBエントリー: 4G8Y 4G90
• 分子名称: Ribonuclease pancreatic, 1-{[1-(alpha-L-arabinofuranosyl)-1H-1,2,3-triazol-4-yl]methyl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidine (3 entities in total)
• 機能のキーワード: nuclease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27741.93

構造登録者

Chatzileontiadou, D.S.M.,Kantsadi, A.L.,Leonidas, D.D. (登録日: 2012-07-23, 公開日: 2012-11-21, 最終更新日: 2023-09-13)

• 主引用文献: Parmenopoulou, V.,Chatzileontiadou, D.S.,Manta, S.,Bougiatioti, S.,Maragozidis, P.,Gkaragkouni, D.N.,Kaffesaki, E.,Kantsadi, A.L.,Skamnaki, V.T.,Zographos, S.E.,Zounpoulakis, P.,Balatsos, N.A.,Komiotis, D.,Leonidas, D.D.; Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.; Bioorg.Med.Chem., 20:7184-7193, 2012; PubMed: 23122937; DOI: 10.1016/j.bmc.2012.09.067

実験手法

X-RAY DIFFRACTION (1.7 Å)