4G8A

Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS

4G8A の概要

• エントリーDOI: 10.2210/pdb4g8a/pdb
• 分子名称: Toll-like receptor 4, Lymphocyte antigen 96, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: leucine rich repeat md-2 related lipid recognition, receptor, innate immunity, lipid binding, glycosylation, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 184511.91

構造登録者

Ohto, U.,Shimizu, T. (登録日: 2012-07-23, 公開日: 2012-10-17, 最終更新日: 2024-11-20)

主引用文献

Ohto, U.,Yamakawa, N.,Akashi-Takamura, S.,Miyake, K.,Shimizu, T.
Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I
J.Biol.Chem., 287:40611-40617, 2012

PubMed Abstract: TLR4 polymorphism replacing Asp-299 with Gly and Thr-399 with Ile (D299G/T399I) causes LPS hyporesponsiveness.

PubMed: 23055527
DOI: 10.1074/jbc.M112.404608

実験手法

X-RAY DIFFRACTION (2.4 Å)