4G3T

Mycobacterium smegmatis DprE1 - hexagonal crystal form

4G3T の概要

• エントリーDOI: 10.2210/pdb4g3t/pdb
• 関連するPDBエントリー: 4G3U
• 分子名称: oxidoreductase DprE1 (2 entities in total)
• 機能のキーワード: vao superfamily, oxidoreductase
• 由来する生物種: Mycobacterium smegmatis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44441.18

構造登録者

Li, H.,Jogl, G. (登録日: 2012-07-15, 公開日: 2012-12-05, 最終更新日: 2024-02-28)

主引用文献

Li, H.,Jogl, G.
Crystal structure of decaprenylphosphoryl-beta- D-ribose 2'-epimerase from Mycobacterium smegmatis.
Proteins, 81:538-543, 2013

PubMed Abstract: Decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) is an essential enzyme in the biosynthesis of cell wall components and a target for development of anti-tuberculosis drugs. We determined the crystal structure of a truncated form of DprE1 from Mycobacterium smegmatis in two crystal forms to up to 2.35 Å resolution. The structure extends from residue 75 to the C-terminus and shares homology with FAD-dependent oxidoreductases of the vanillyl-alcohol oxidase family including the DprE1 homologue from M. tuberculosis. The M. smegmatis DprE1 structure reported here provides further insights into the active site geometry of this tuberculosis drug target.

PubMed: 23184707
DOI: 10.1002/prot.24220

実験手法

X-RAY DIFFRACTION (2.346 Å)