4G3F

Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 2-(aminothiazoly)phenol (cmp2)

4G3F の概要

• エントリーDOI: 10.2210/pdb4g3f/pdb
• 関連するPDBエントリー: 4G3C 4G3D 4G3E 4G3G
• 分子名称: NF-kappa-beta-inducing kinase, 3-{2-[(5-fluoro-2-hydroxyphenyl)amino]-1,3-thiazol-4-yl}benzonitrile (3 entities in total)
• 機能のキーワード: non-rd kinase, protein serine/threonine kinase, nf-kappab, structure-based drug design, map3k14, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Cytoplasm: Q9WUL6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37290.92

構造登録者

Hymowitz, S.G.,de Leon-Boenig, G. (登録日: 2012-07-13, 公開日: 2012-08-08, 最終更新日: 2024-02-28)

• 主引用文献: de Leon-Boenig, G.,Bowman, K.K.,Feng, J.A.,Crawford, T.,Everett, C.,Franke, Y.,Oh, A.,Stanley, M.,Staben, S.T.,Starovasnik, M.A.,Wallweber, H.J.,Wu, J.,Wu, L.C.,Johnson, A.R.,Hymowitz, S.G.; The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.; Structure, 20:1704-1714, 2012; PubMed: 22921830; DOI: 10.1016/j.str.2012.07.013

実験手法

X-RAY DIFFRACTION (1.642 Å)