4G2L

Human PDE9 in complex with selective compound

4G2L の概要

• エントリーDOI: 10.2210/pdb4g2l/pdb
• 関連するPDBエントリー: 3JSW
• 分子名称: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: phosphodiesterase, inhibitor complex, cgmp->gmp, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform PDE9A1: Cell projection, ruffle membrane. Isoform PDE9A2: Cell projection, ruffle membrane. Isoform PDE9A3: Cytoplasm. Isoform PDE9A17: Cytoplasm: O76083
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78636.14

構造登録者

Liu, S. (登録日: 2012-07-12, 公開日: 2013-05-29, 最終更新日: 2024-02-28)

• 主引用文献: Claffey, M.M.,Helal, C.J.,Verhoest, P.R.,Kang, Z.,Fors, K.S.,Jung, S.,Zhong, J.,Bundesmann, M.W.,Hou, X.,Lui, S.,Kleiman, R.J.,Vanase-Frawley, M.,Schmidt, A.W.,Menniti, F.,Schmidt, C.J.,Hoffman, W.E.,Hajos, M.,McDowell, L.,O'Connor, R.E.,Macdougall-Murphy, M.,Fonseca, K.R.,Becker, S.L.,Nelson, F.R.,Liras, S.; Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.; J.Med.Chem., 55:9055-9068, 2012; PubMed: 23025719; DOI: 10.1021/jm3009635

実験手法

X-RAY DIFFRACTION (3 Å)