4G2B

Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI

4G2B の概要

• エントリーDOI: 10.2210/pdb4g2b/pdb
• 関連するPDBエントリー: 4G29
• 分子名称: Secreted effector protein sseI (2 entities in total)
• 機能のキーワード: cysteine protease superfamily, protein binding
• 由来する生物種: Salmonella enterica subsp. enterica serovar Typhimurium
• 細胞内の位置: Secreted: Q8ZQ79
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42654.30

構造登録者

Stebbins, C.E.,Bhaskaran, S.S. (登録日: 2012-07-11, 公開日: 2012-11-28, 最終更新日: 2024-10-30)

主引用文献

Bhaskaran, S.S.,Stebbins, C.E.
Structure of the catalytic domain of the Salmonella virulence factor SseI.
Acta Crystallogr.,Sect.D, 68:1613-1621, 2012

PubMed Abstract: SseI is secreted into host cells by Salmonella and contributes to the establishment of systemic infections. The crystal structure of the C-terminal domain of SseI has been solved to 1.70 Å resolution, revealing it to be a member of the cysteine protease superfamily with a catalytic triad consisting of Cys178, His216 and Asp231 that is critical to its virulence activities. Structure-based analysis revealed that SseI is likely to possess either acyl hydrolase or acyltransferase activity, placing this virulence factor in the rapidly growing class of enzymes of this family utilized by bacterial pathogens inside eukaryotic cells.

PubMed: 23151626
DOI: 10.1107/S0907444912039042

実験手法

X-RAY DIFFRACTION (2.05 Å)