4FPK

Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-methylbenzyl)ammonio]ethanesulfonate

Summary for 4FPK

Entry DOI	10.2210/pdb4fpk/pdb
Related	2VW0 2VW1 2VW2 4FOQ 4FOV 4FOW 4FOY 4FP2 4FP3 4FPC 4FPE 4FPF 4FPG 4FPH 4FPJ 4FPL 4FPO 4FPY 4FQ4
Descriptor	Sialidase B, 2-[(3-methylbenzyl)amino]ethanesulfonic acid, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	hydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Streptococcus pneumoniae
Total number of polymer chains	1
Total formula weight	78088.31
Authors	Brear, P. (deposition date: 2012-06-22, release date: 2012-10-31, Last modification date: 2024-02-28)
Primary citation	Brear, P.,Telford, J.,Taylor, G.L.,Westwood, N.J. Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13:2374-2383, 2012 Cited by PubMed: 23070966 DOI: 10.1002/cbic.201200433 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation