4FPK

Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-methylbenzyl)ammonio]ethanesulfonate

4FPK の概要

• エントリーDOI: 10.2210/pdb4fpk/pdb
• 関連するPDBエントリー: 2VW0 2VW1 2VW2 4FOQ 4FOV 4FOW 4FOY 4FP2 4FP3 4FPC 4FPE 4FPF 4FPG 4FPH 4FPJ 4FPL 4FPO 4FPY 4FQ4
• 分子名称: Sialidase B, 2-[(3-methylbenzyl)amino]ethanesulfonic acid, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: hydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Streptococcus pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 78088.31

構造登録者

Brear, P. (登録日: 2012-06-22, 公開日: 2012-10-31, 最終更新日: 2024-02-28)

• 主引用文献: Brear, P.,Telford, J.,Taylor, G.L.,Westwood, N.J.; Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.; Chembiochem, 13:2374-2383, 2012; PubMed: 23070966; DOI: 10.1002/cbic.201200433

実験手法

X-RAY DIFFRACTION (2.4 Å)