4FNC
Human TDG in a post-reactive complex with 5-hydroxymethyluracil (5hmU)
Summary for 4FNC
Entry DOI | 10.2210/pdb4fnc/pdb |
Descriptor | G/T mismatch-specific thymine DNA glycosylase, DNA (28-MER), DNA (29-MER), ... (5 entities in total) |
Functional Keywords | base excision repair, hydrolase-dna complex, hydrolase/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q13569 |
Total number of polymer chains | 3 |
Total formula weight | 40636.97 |
Authors | Hashimoto, H.,Hong, S.,Bhagwat, A.S.,Zhang, X.,Cheng, X. (deposition date: 2012-06-19, release date: 2012-09-19, Last modification date: 2023-09-13) |
Primary citation | Hashimoto, H.,Hong, S.,Bhagwat, A.S.,Zhang, X.,Cheng, X. Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation. Nucleic Acids Res., 40:10203-10214, 2012 Cited by PubMed: 22962365DOI: 10.1093/nar/gks845 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.493 Å) |
Structure validation
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