4FNC

Human TDG in a post-reactive complex with 5-hydroxymethyluracil (5hmU)

4FNC の概要

• エントリーDOI: 10.2210/pdb4fnc/pdb
• 分子名称: G/T mismatch-specific thymine DNA glycosylase, DNA (28-MER), DNA (29-MER), ... (5 entities in total)
• 機能のキーワード: base excision repair, hydrolase-dna complex, hydrolase/dna
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: Q13569
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 40636.97

構造登録者

Hashimoto, H.,Hong, S.,Bhagwat, A.S.,Zhang, X.,Cheng, X. (登録日: 2012-06-19, 公開日: 2012-09-19, 最終更新日: 2023-09-13)

• 主引用文献: Hashimoto, H.,Hong, S.,Bhagwat, A.S.,Zhang, X.,Cheng, X.; Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.; Nucleic Acids Res., 40:10203-10214, 2012; PubMed: 22962365; DOI: 10.1093/nar/gks845

実験手法

X-RAY DIFFRACTION (2.493 Å)