4FJY

Crystal structure of PI3K-gamma in complex with quinoline-indoline inhibitor 24f

Summary for 4FJY

Entry DOI	10.2210/pdb4fjy/pdb
Related	4FJZ 4FLH
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 4-[3,3-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1H-indol-1-yl]-7-fluoro-3-methyl-2-(pyridin-3-yl)quinoline, ... (4 entities in total)
Functional Keywords	inflammation, cancer, p110, c2 domain, leukocytes, kinase, p85, phosphotransferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P48736
Total number of polymer chains	1
Total formula weight	110580.81
Authors	Whittington, D.A.,Tang, J.,Yakowec, P. (deposition date: 2012-06-12, release date: 2012-10-24, Last modification date: 2024-02-28)
Primary citation	Gonzalez-Lopez de Turiso, F.,Shin, Y.,Brown, M.,Cardozo, M.,Chen, Y.,Fong, D.,Hao, X.,He, X.,Henne, K.,Hu, Y.L.,Johnson, M.G.,Kohn, T.,Lohman, J.,McBride, H.J.,McGee, L.R.,Medina, J.C.,Metz, D.,Miner, K.,Mohn, D.,Pattaropong, V.,Seganish, J.,Simard, J.L.,Wannberg, S.,Whittington, D.A.,Yu, G.,Cushing, T.D. Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors J.Med.Chem., 55:7667-7685, 2012 Cited by PubMed: 22876881 DOI: 10.1021/jm300679u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation