4FJY

Crystal structure of PI3K-gamma in complex with quinoline-indoline inhibitor 24f

4FJY の概要

• エントリーDOI: 10.2210/pdb4fjy/pdb
• 関連するPDBエントリー: 4FJZ 4FLH
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 4-[3,3-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1H-indol-1-yl]-7-fluoro-3-methyl-2-(pyridin-3-yl)quinoline, ... (4 entities in total)
• 機能のキーワード: inflammation, cancer, p110, c2 domain, leukocytes, kinase, p85, phosphotransferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P48736
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 110580.81

構造登録者

Whittington, D.A.,Tang, J.,Yakowec, P. (登録日: 2012-06-12, 公開日: 2012-10-24, 最終更新日: 2024-02-28)

• 主引用文献: Gonzalez-Lopez de Turiso, F.,Shin, Y.,Brown, M.,Cardozo, M.,Chen, Y.,Fong, D.,Hao, X.,He, X.,Henne, K.,Hu, Y.L.,Johnson, M.G.,Kohn, T.,Lohman, J.,McBride, H.J.,McGee, L.R.,Medina, J.C.,Metz, D.,Miner, K.,Mohn, D.,Pattaropong, V.,Seganish, J.,Simard, J.L.,Wannberg, S.,Whittington, D.A.,Yu, G.,Cushing, T.D.; Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors; J.Med.Chem., 55:7667-7685, 2012; PubMed: 22876881; DOI: 10.1021/jm300679u

実験手法

X-RAY DIFFRACTION (2.9 Å)