4FJ0

Crystal structure of the ternary complex between a fungal 17beta-hydroxysteroid dehydrogenase (Holo form) and 3,7-dihydroxy flavone

4FJ0 の概要

• エントリーDOI: 10.2210/pdb4fj0/pdb
• 関連するPDBエントリー: 3IS3 3ITD 3QWF 3QWH 3QWI 4FIZ 4FJ1 4FJ2
• 分子名称: 17beta-hydroxysteroid dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: short chain dehydrogenase/reductase, rossmann fold, oxidoreductase, nadp(h), oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Cochliobolus lunatus (Filamentous fungus)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 119724.82

構造登録者

Cassetta, A.,Lamba, D.,Krastanova, I. (登録日: 2012-06-11, 公開日: 2013-07-03, 最終更新日: 2023-09-13)

• 主引用文献: Cassetta, A.,Stojan, J.,Krastanova, I.,Kristan, K.,Brunskole Svegelj, M.,Lamba, D.,Rizner, T.L.; Structural basis for inhibition of 17 beta-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17 beta-HSDcl.; J. Steroid Biochem. Mol. Biol., 171:80-93, 2017; PubMed: 28259640; DOI: 10.1016/j.jsbmb.2017.02.020

実験手法

X-RAY DIFFRACTION (2.2 Å)