4FGK

Oxidized quinone reductase 2 in complex with chloroquine

4FGK の概要

• エントリーDOI: 10.2210/pdb4fgk/pdb
• 関連するPDBエントリー: 4FGJ 4FGK
• 分子名称: Ribosyldihydronicotinamide dehydrogenase [quinone], FLAVIN-ADENINE DINUCLEOTIDE, (4S)-N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine, ... (5 entities in total)
• 機能のキーワード: chloroquine, fmn reductase superfamily (conserved domain database), metallo-flavoprotein, rossmann fold, two-electron reduction of quinones to hydroquinones, fad binding, zn binding, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P16083
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54558.99

構造登録者

Leung, K.K.,Shilton, B.H. (登録日: 2012-06-04, 公開日: 2013-03-13, 最終更新日: 2024-02-28)

• 主引用文献: Leung, K.K.,Shilton, B.H.; Crystal structures of quinone reductase 2 bound to antimalarial drugs reveal conformational change upon reduction; J.Biol.Chem., 2013

実験手法

X-RAY DIFFRACTION (1.401 Å)