4FAM
Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoic acid (17)
Summary for 4FAM
Entry DOI | 10.2210/pdb4fam/pdb |
Related | 4FA3 4FAL |
Descriptor | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acid, ... (5 entities in total) |
Functional Keywords | aldo-keto reductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P42330 |
Total number of polymer chains | 2 |
Total formula weight | 78634.88 |
Authors | Turnbull, A.P.,Jamieson, S.M.F.,Brooke, D.G.,Heinrich, D.,Atwell, G.J.,Silva, S.,Hamilton, E.J.,Rigoreau, L.J.M.,Trivier, E.,Soudy, C.,Samlal, S.S.,Owen, P.J.,Schroeder, E.,Raynham, T.,Flanagan, J.U.,Denny, W.A. (deposition date: 2012-05-22, release date: 2012-10-10, Last modification date: 2023-09-13) |
Primary citation | Jamieson, S.M.,Brooke, D.G.,Heinrich, D.,Atwell, G.J.,Silva, S.,Hamilton, E.J.,Turnbull, A.P.,Rigoreau, L.J.,Trivier, E.,Soudy, C.,Samlal, S.S.,Owen, P.J.,Schroeder, E.,Raynham, T.,Flanagan, J.U.,Denny, W.A. 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids; a New Class of Highly Potent and Selective Inhibitors of the Type 5 17-beta-hydroxysteroid Dehydrogenase AKR1C3 J.Med.Chem., 55:7746-7758, 2012 Cited by PubMed: 22877157DOI: 10.1021/jm3007867 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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