4FA6

Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3Ka and mTOR

4FA6 の概要

• エントリーDOI: 10.2210/pdb4fa6/pdb
• 関連するPDBエントリー: 4FAD
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)pyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total)
• 機能のキーワード: phosphoinositide kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P48736
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111037.46

構造登録者

Pannifer, A.,Greasley, S.E. (登録日: 2012-05-21, 公開日: 2013-04-03, 最終更新日: 2024-02-28)

主引用文献

Le, P.T.,Cheng, H.,Ninkovic, S.,Plewe, M.,Huang, X.,Wang, H.,Bagrodia, S.,Sun, S.,Knighton, D.R.,LaFleur Rogers, C.M.,Pannifer, A.,Greasley, S.,Dalvie, D.,Zhang, E.
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kalpha and mTOR
Bioorg.Med.Chem.Lett., 22:5098-5103, 2012

PubMed Abstract: Lead optimization efforts that employed structure base drug design and physicochemical property based optimization leading to the discovery of a novel series of 4-methylpyrido pyrimidinone (MPP) are discussed. Synthesis and profile of 1, a PI3Kα/mTOR dual inhibitor, is highlighted.

PubMed: 22749419
DOI: 10.1016/j.bmcl.2012.05.100

実験手法

X-RAY DIFFRACTION (2.7 Å)