4F64
Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 6
Summary for 4F64
Entry DOI | 10.2210/pdb4f64/pdb |
Related | 4F63 4F65 |
Descriptor | Fibroblast growth factor receptor 1, 5-bromo-N~4~-[3-(3-methoxypropyl)-1H-pyrazol-5-yl]-N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | kinase, atp binding, phosphorylation, trans-membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 71459.57 |
Authors | Norman, R.A.,Breed, J.,Ogg, D. (deposition date: 2012-05-14, release date: 2012-06-06, Last modification date: 2023-09-13) |
Primary citation | Norman, R.A.,Schott, A.K.,Andrews, D.M.,Breed, J.,Foote, K.M.,Garner, A.P.,Ogg, D.,Orme, J.P.,Pink, J.H.,Roberts, K.,Rudge, D.A.,Thomas, A.P.,Leach, A.G. Protein-Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase. J.Med.Chem., 55:5003-5012, 2012 Cited by PubMed: 22612866DOI: 10.1021/jm3004043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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