4F63

Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 1

4F63 の概要

• エントリーDOI: 10.2210/pdb4f63/pdb
• 関連するPDBエントリー: 4F64 4F65
• 分子名称: Fibroblast growth factor receptor 1, 5-bromo-N~4~-(3-methyl-1H-pyrazol-5-yl)-N~2~-[2-(pyridin-3-yl)ethyl]pyrimidine-2,4-diamine, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: kinase, atp binding, phosphorylation, trans-membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P11362
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71267.43

構造登録者

Norman, R.A.,Breed, J.,Ogg, D. (登録日: 2012-05-14, 公開日: 2012-06-06, 最終更新日: 2023-09-13)

• 主引用文献: Norman, R.A.,Schott, A.K.,Andrews, D.M.,Breed, J.,Foote, K.M.,Garner, A.P.,Ogg, D.,Orme, J.P.,Pink, J.H.,Roberts, K.,Rudge, D.A.,Thomas, A.P.,Leach, A.G.; Protein-Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase.; J.Med.Chem., 55:5003-5012, 2012; PubMed: 22612866; DOI: 10.1021/jm3004043

実験手法

X-RAY DIFFRACTION (2.55 Å)