4F59

Triple mutant Src SH2 domain

Summary for 4F59

Entry DOI	10.2210/pdb4f59/pdb
Related	4F5A 4F5B
Descriptor	Proto-oncogene tyrosine-protein kinase Src (2 entities in total)
Functional Keywords	sh2 domain, cell signalling, phosphotyrosine binding, protein binding
Biological source	Homo sapiens (human)
Cellular location	Cell membrane: P12931
Total number of polymer chains	1
Total formula weight	12699.32
Authors	Kaneko, T.,Huang, H.,Cao, X.,Li, C.,Voss, C.,Sidhu, S.S.,Li, S.S. (deposition date: 2012-05-12, release date: 2012-10-03, Last modification date: 2024-02-28)
Primary citation	Kaneko, T.,Huang, H.,Cao, X.,Li, X.,Li, C.,Voss, C.,Sidhu, S.S.,Li, S.S. Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5:ra68-ra68, 2012 Cited by PubMed: 23012655 DOI: 10.1126/scisignal.2003021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation