4F3V

Crystal structure of N-terminal domain of EccA1 ATPase from ESX-1 secretion system of Mycobacterium tuberculosis

4F3V の概要

• エントリーDOI: 10.2210/pdb4f3v/pdb
• 分子名称: ESX-1 secretion system protein EccA1, SAMARIUM (III) ION, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: tetratricopeptide repeat, tpr domain, atpase, protein secretion, protein transport
• 由来する生物種: Mycobacterium tuberculosis
• 細胞内の位置: Cytoplasm (Potential): O69733
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61625.42

構造登録者

Korotkov, K.V.,Evans, T.J. (登録日: 2012-05-09, 公開日: 2012-06-06, 最終更新日: 2024-02-28)

主引用文献

Wagner, J.M.,Evans, T.J.,Korotkov, K.V.
Crystal structure of the N-terminal domain of EccA1 ATPase from the ESX-1 secretion system of Mycobacterium tuberculosis.
Proteins, 82:159-163, 2014

PubMed Abstract: EccA1 is an important component of the type VII secretion system (T7SS) that is responsible for transport of virulence factors in pathogenic mycobacteria. EccA1 has an N-terminal domain of unknown function and a C-terminal AAA+ (ATPases associated with various cellular activities) domain. Here we report the crystal structure of the N-terminal domain of EccA1 from Mycobacterium tuberculosis, which shows an arrangement of six tetratricopeptide repeats that may mediate interactions of EccA1 with secreted substrates. Furthermore, the size and shape of the N-terminal domain suggest its orientation in the context of a hexamer model of full-length EccA1.

PubMed: 23818233
DOI: 10.1002/prot.24351

実験手法

X-RAY DIFFRACTION (2 Å)