4F3I

Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor

4F3I の概要

• エントリーDOI: 10.2210/pdb4f3i/pdb
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate, ... (4 entities in total)
• 機能のキーワード: protein-inhibitor complex, acetyl-lysine binding, nucleus, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15638.42

構造登録者

Joshua, J.,Zhou, M.-M.,Plotnikov, A.N. (登録日: 2012-05-09, 公開日: 2012-09-12, 最終更新日: 2023-09-13)

• 主引用文献: Zhang, G.,Liu, R.,Zhong, Y.,Plotnikov, A.N.,Zhang, W.,Zeng, L.,Rusinova, E.,Gerona-Nevarro, G.,Moshkina, N.,Joshua, J.,Chuang, P.Y.,Ohlmeyer, M.,He, J.C.,Zhou, M.M.; Down-regulation of NF-{kappa}B Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition.; J.Biol.Chem., 287:28840-28851, 2012; PubMed: 22645123; DOI: 10.1074/jbc.M112.359505

実験手法

X-RAY DIFFRACTION (1.4 Å)