4EQC

Crystal structure of PAK1 kinase domain in complex with FRAX597 inhibitor

4EQC の概要

• エントリーDOI: 10.2210/pdb4eqc/pdb
• 分子名称: Serine/threonine-protein kinase PAK 1, 6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: serine/threonine kinase, phosphorylation, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q13153
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34456.73

構造登録者

Maksimoska, J.,Marmorstein, R. (登録日: 2012-04-18, 公開日: 2013-08-28, 最終更新日: 2023-09-13)

• 主引用文献: Licciulli, S.,Maksimoska, J.,Zhou, C.,Troutman, S.,Kota, S.,Liu, Q.,Duron, S.,Campbell, D.,Chernoff, J.,Field, J.,Marmorstein, R.,Kissil, J.L.; FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas.; J.Biol.Chem., 288:29105-29114, 2013; PubMed: 23960073; DOI: 10.1074/jbc.M113.510933

実験手法

X-RAY DIFFRACTION (2.01 Å)