4EPR

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.

Summary for 4EPR

• Entry DOI: 10.2210/pdb4epr/pdb
• Related: 4EPT 4EPV 4EPW 4EPX 4EPY
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: closed conformation, kras, p21, gtp-binding protein, oncogene, hydrolase, inhibitor of sos-mediated activation, binder
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
• Total number of polymer chains: 1
• Total formula weight: 19838.29

Authors

Sun, Q.,Burke, J.P.,Phan, J.,Burns, M.C.,Olejniczak, E.T.,Waterson, A.G.,Lee, T.,Rossanese, O.W.,Fesik, S.W. (deposition date: 2012-04-17, release date: 2012-05-23, Last modification date: 2024-02-28)

• Primary citation: Sun, Q.,Burke, J.P.,Phan, J.,Burns, M.C.,Olejniczak, E.T.,Waterson, A.G.,Lee, T.,Rossanese, O.W.,Fesik, S.W.; Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.; Angew.Chem.Int.Ed.Engl., 51:6140-6143, 2012; PubMed: 22566140; DOI: 10.1002/anie.201201358

Experimental method

X-RAY DIFFRACTION (2 Å)