4EPR

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.

4EPR の概要

関連するPDBエントリー4EPT 4EPV 4EPW 4EPX 4EPY
分子名称GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
機能のキーワードclosed conformation, kras, p21, gtp-binding protein, oncogene, hydrolase, inhibitor of sos-mediated activation, binder
由来する生物種Homo sapiens (human)
細胞内の位置Cell membrane ; Lipid-anchor ; Cytoplasmic side  P01116
ポリマー鎖数1
分子量合計19838.29
構造登録者
Sun, Q.,Burke, J.P.,Phan, J.,Burns, M.C.,Olejniczak, E.T.,Waterson, A.G.,Lee, T.,Rossanese, O.W.,Fesik, S.W. (登録日: 2012-04-17, 公開日: 2012-05-23, 最終更新日: 2018-01-24)
主引用文献
Sun, Q.,Burke, J.P.,Phan, J.,Burns, M.C.,Olejniczak, E.T.,Waterson, A.G.,Lee, T.,Rossanese, O.W.,Fesik, S.W.
Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51:6140-6143, 2012
PubMed: 22566140 (主引用文献が同じPDBエントリー)
DOI: 10.1002/anie.201201358
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.255702.7%4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード