4EHR

Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide

4EHR の概要

• エントリーDOI: 10.2210/pdb4ehr/pdb
• 分子名称: Bcl-2-like protein 1, 4-[5-butyl-3-(hydroxymethyl)-1-phenyl-1H-pyrazol-4-yl]-3-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}benzamide, IMIDAZOLE, ... (4 entities in total)
• 機能のキーワード: apoptosis, programmed cell death, bcl-2 family
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion membrane; Single-pass membrane protein: Q07817
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20337.49

構造登録者

Schroeder, G.M.,Wei, D.,Banfi, P.,Cai, Z.,Lippy, J.,Menichincheri, M.,Modugno, M.,Naglich, J.,Penhallow, B.,Perez, H.L.,Sack, J.,Schmidt, R.J.,Tebben, A.,Yan, C.,Zhang, L.,Galvani, A.,Lombardo, L.J.,Borzilleri, R.M. (登録日: 2012-04-03, 公開日: 2012-06-06, 最終更新日: 2024-02-28)

• 主引用文献: Schroeder, G.M.,Wei, D.,Banfi, P.,Cai, Z.W.,Lippy, J.,Menichincheri, M.,Modugno, M.,Naglich, J.,Penhallow, B.,Perez, H.L.,Sack, J.,Schmidt, R.J.,Tebben, A.,Yan, C.,Zhang, L.,Galvani, A.,Lombardo, L.J.,Borzilleri, R.M.; Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.; Bioorg.Med.Chem.Lett., 22:3951-3956, 2012; PubMed: 22608393; DOI: 10.1016/j.bmcl.2012.04.106

実験手法

X-RAY DIFFRACTION (2.09 Å)