4EEF
Crystal structure of the designed inhibitor protein F-HB80.4 in complex with the 1918 influenza virus hemagglutinin.
Summary for 4EEF
Entry DOI | 10.2210/pdb4eef/pdb |
Descriptor | Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, F-HB80.4, DESIGNED HEMAGGLUTININ BINDING PROTEIN, ... (5 entities in total) |
Functional Keywords | immunoglobulin, hemagglutinin, fusion of virus membrane with host membrane, membrane fusion, sialic acid, virion, immune system, immune system-inhibitor complex, immune system/inhibitor |
Biological source | Influenza A virus More |
Cellular location | Virion membrane; Single-pass type I membrane protein (Potential): Q9WFX3 Q9WFX3 |
Total number of polymer chains | 9 |
Total formula weight | 198733.63 |
Authors | Dreyfus, C.,Wilson, I.A. (deposition date: 2012-03-28, release date: 2012-06-27, Last modification date: 2020-07-29) |
Primary citation | Whitehead, T.A.,Chevalier, A.,Song, Y.,Dreyfus, C.,Fleishman, S.J.,De Mattos, C.,Myers, C.A.,Kamisetty, H.,Blair, P.,Wilson, I.A.,Baker, D. Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing. Nat.Biotechnol., 30:543-548, 2012 Cited by PubMed: 22634563DOI: 10.1038/nbt.2214 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.704 Å) |
Structure validation
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