4EEF

Crystal structure of the designed inhibitor protein F-HB80.4 in complex with the 1918 influenza virus hemagglutinin.

4EEF の概要

• エントリーDOI: 10.2210/pdb4eef/pdb
• 分子名称: Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, F-HB80.4, DESIGNED HEMAGGLUTININ BINDING PROTEIN, ... (5 entities in total)
• 機能のキーワード: immunoglobulin, hemagglutinin, fusion of virus membrane with host membrane, membrane fusion, sialic acid, virion, immune system, immune system-inhibitor complex, immune system/inhibitor
• 由来する生物種: Influenza A virus; 詳細
• 細胞内の位置: Virion membrane; Single-pass type I membrane protein (Potential): Q9WFX3 Q9WFX3
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 198733.63

構造登録者

Dreyfus, C.,Wilson, I.A. (登録日: 2012-03-28, 公開日: 2012-06-27, 最終更新日: 2020-07-29)

• 主引用文献: Whitehead, T.A.,Chevalier, A.,Song, Y.,Dreyfus, C.,Fleishman, S.J.,De Mattos, C.,Myers, C.A.,Kamisetty, H.,Blair, P.,Wilson, I.A.,Baker, D.; Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing.; Nat.Biotechnol., 30:543-548, 2012; PubMed: 22634563; DOI: 10.1038/nbt.2214

実験手法

X-RAY DIFFRACTION (2.704 Å)