4E99

Human Serum Albumin Complex with Perfluorooctane Sulfonate Potassium

4E99 の概要

• エントリーDOI: 10.2210/pdb4e99/pdb
• 分子名称: Serum albumin, heptadecafluoro-1-octanesulfonic acid (3 entities in total)
• 機能のキーワード: plasma protein, transporter, drug binding, extracellular, transport protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02768
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 67571.48

構造登録者

Luo, Z.P.,Shi, X.L.,Huang, M.D. (登録日: 2012-03-20, 公開日: 2012-06-06, 最終更新日: 2024-11-20)

主引用文献

Luo, Z.P.,Shi, X.L.,Hu, Q.,Zhao, B.,Huang, M.D.
Structural evidence of perfluorooctane sulfonate transport by human serum albumin
Chem.Res.Toxicol., 25:990-992, 2012

PubMed Abstract: Perfluorooctane sulfonate (PFOS) is a man-made fluorosurfactant and globally persistent organic pollutant. PFOS is mainly distributed in blood with a long half-life for elimination. PFOS was found mainly bound to human serum albumin (HSA) in plasma, the most abundant protein in human blood plasma, which transports a variety of endogenous and exogenous ligands. However, the structural basis of such binding remains unclear. Here, we report the crystal structure of the HSA-PFOS complex and show that PFOS binds to HSA at a molar ratio of 2:1. In addition, PFOS binding renders the HSA structure more compact. Our results provide a structural mechanism to understand the retention of surfactants in human serum.

PubMed: 22482699
DOI: 10.1021/tx300112p

実験手法

X-RAY DIFFRACTION (2.3 Å)