4E5X

Crystal structure of a complex between the human adenovirus type 2 E3-19K protein and MHC class I molecule HLA-A2/Tax

4E5X の概要

• エントリーDOI: 10.2210/pdb4e5x/pdb
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Protein Tax-1, ... (5 entities in total)
• 機能のキーワード: ad2 e3-19k-hla-a2 complex, unique tertiary structure, adenovirus e3-19k, immune evasion function, mhc class i molecule, endoplasmic reticulum, immune system-transcription complex, immune system/transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769; Host nucleus (By similarity): P0C213; Host endoplasmic reticulum membrane; Single- pass type I membrane protein: P68979
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 113485.32

構造登録者

Li, L.,Bouvier, M. (登録日: 2012-03-14, 公開日: 2012-10-10, 最終更新日: 2023-09-13)

• 主引用文献: Li, L.,Muzahim, Y.,Bouvier, M.; Crystal structure of adenovirus E3-19K bound to HLA-A2 reveals mechanism for immunomodulation.; Nat.Struct.Mol.Biol., 19:1176-1181, 2012; PubMed: 23042604; DOI: 10.1038/nsmb.2396

実験手法

X-RAY DIFFRACTION (1.95 Å)