4E4X
Crystal Structure of B-Raf Kinase Domain in Complex with a Dihydropyrido[2,3-d]pyrimidinone-based Inhibitor
Summary for 4E4X
Entry DOI | 10.2210/pdb4e4x/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, N-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide (2 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P15056 |
Total number of polymer chains | 2 |
Total formula weight | 71370.25 |
Authors | Voegtli, W.C.,Sturgis, H.L. (deposition date: 2012-03-13, release date: 2012-05-09, Last modification date: 2024-02-28) |
Primary citation | Ren, L.,Ahrendt, K.A.,Grina, J.,Laird, E.R.,Buckmelter, A.J.,Hansen, J.D.,Newhouse, B.,Moreno, D.,Wenglowsky, S.,Dinkel, V.,Gloor, S.L.,Hastings, G.,Rana, S.,Rasor, K.,Risom, T.,Sturgis, H.L.,Voegtli, W.C.,Mathieu, S. The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-Raf(V600E) kinase. Bioorg.Med.Chem.Lett., 22:3387-3391, 2012 Cited by PubMed: 22534450DOI: 10.1016/j.bmcl.2012.04.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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