4E1K

GlmU in complex with a Quinazoline Compound

4E1K の概要

• エントリーDOI: 10.2210/pdb4e1k/pdb
• 分子名称: Bifunctional protein GlmU, SULFATE ION, TETRAETHYLENE GLYCOL, ... (5 entities in total)
• 機能のキーワード: peptidoglycan synthesis, cell shape, metal-binding, cell wall biogenesis/degradation, multifunctional enzyme, acyltransferase, uridyltransferase, nucleotidyl transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Haemophilus influenzae
• 細胞内の位置: Cytoplasm (By similarity): P43889
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50214.88

構造登録者

Larsen, N.A.,Doig, P. (登録日: 2012-03-06, 公開日: 2013-05-29, 最終更新日: 2024-02-28)

• 主引用文献: Larsen, N.A.,Nash, T.J.,Morningstar, M.,Shapiro, A.B.,Joubran, C.,Blackett, C.J.,Patten, A.D.,Boriack-Sjodin, P.A.,Doig, P.; An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode.; Biochem.J., 446:405-413, 2012; PubMed: 22721802; DOI: 10.1042/BJ20120596

実験手法

X-RAY DIFFRACTION (2 Å)