4E13

Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductase

4E13 の概要

• エントリーDOI: 10.2210/pdb4e13/pdb
• 関連するPDBエントリー: 4DYD 4E12
• 分子名称: Diketoreductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, nadh
• 由来する生物種: Acinetobacter baylyi
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31632.39

構造登録者

Lu, M.,White, M.A.,Huang, Y.,Wu, X.,Liu, N.,Cheng, X.,Chen, Y. (登録日: 2012-03-05, 公開日: 2012-11-14, 最終更新日: 2023-11-08)

主引用文献

Lu, M.,Huang, Y.,White, M.A.,Wu, X.,Liu, N.,Cheng, X.,Chen, Y.
Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase
Chem.Commun.(Camb.), 48:11352-11354, 2012

PubMed Abstract: Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product.

PubMed: 23073461
DOI: 10.1039/c2cc36334h

実験手法

X-RAY DIFFRACTION (2.08 Å)