4E0Q

Crystal structure of MPN domain from COP9 signalosome

4E0Q の概要

• エントリーDOI: 10.2210/pdb4e0q/pdb
• 分子名称: COP9 signalosome complex subunit 6 (2 entities in total)
• 機能のキーワード: mpn (mpr1p and pad1p n-terminal) domain, unknown function
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• 細胞内の位置: Cytoplasm (Probable): Q9VCY3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32878.13

構造登録者

Zhang, H.,Gao, Z.Q.,Dong, Y.H. (登録日: 2012-03-05, 公開日: 2012-03-21, 最終更新日: 2024-11-20)

主引用文献

Zhang, H.,Gao, Z.Q.,Wang, W.J.,Liu, G.F.,Shtykova, E.V.,Xu, J.H.,Li, L.F.,Su, X.D.,Dong, Y.H.
The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6
Febs Lett., 586:1147-1153, 2012

PubMed Abstract: The COP9 signalosome (CSN) is a multiprotein complex containing eight subunits and is highly conserved from fungi to human. CSN is proposed to widely participate in many physiological processes, including protein degradation, DNA damage response and signal transduction. Among those subunits, only CSN5 and CSN6 belong to JAMM family. CSN5 possesses isopeptidase activity, but CSN6 lacks this ability. Here we report the 2.5Å crystal structure of MPN domain from Drosophila melanogaster CSN6. Structural comparison with other MPN domains, along with bioinformation analysis, suggests that MPN domain from CSN6 may serve as a scaffold instead of a metalloprotease.

PubMed: 22575649
DOI: 10.1016/j.febslet.2012.03.029

実験手法

X-RAY DIFFRACTION (2.5 Å)