Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(S)-2-chloro-3-phenylpropanoic acid complex with AMPPNP

Summary for 4E02

Related3TZ0 3TZ2 3TZ4 3TZ5 4DZY 4E01
Descriptor[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, POTASSIUM ION, ... (6 entities in total)
Functional Keywordsghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceRattus norvegicus (brown rat,rat,rats)
Cellular locationMitochondrion matrix Q00972
Total number of polymer chains1
Total molecular weight48128.47
Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T. (deposition date: 2012-03-02, release date: 2013-03-13)
Primary citation
Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T.
Structures of branched-chain alpha-ketoacid dehydrogenase kinase-inhibitor complexes
To be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.203400.7%6.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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