4E02

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(S)-2-chloro-3-phenylpropanoic acid complex with AMPPNP

4E02 の概要

• エントリーDOI: 10.2210/pdb4e02/pdb
• 関連するPDBエントリー: 3TZ0 3TZ2 3TZ4 3TZ5 4DZY 4E01
• 分子名称: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, POTASSIUM ION, ... (6 entities in total)
• 機能のキーワード: ghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Mitochondrion matrix: Q00972
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48128.47

構造登録者

Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T. (登録日: 2012-03-02, 公開日: 2013-03-13, 最終更新日: 2023-09-13)

• 主引用文献: Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T.; Structures of branched-chain alpha-ketoacid dehydrogenase kinase-inhibitor complexes; To be Published,

実験手法

X-RAY DIFFRACTION (2.1547 Å)