4E01

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with AMPPNP

4E01 の概要

• エントリーDOI: 10.2210/pdb4e01/pdb
• 関連するPDBエントリー: 3TZ0 3TZ2 3TZ4 3TZ5 4DZY 4E00
• 分子名称: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, 3,6-dichloro-1-benzothiophene-2-carboxylic acid, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: ghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Mitochondrion matrix: Q00972
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48190.94

構造登録者

Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T. (登録日: 2012-03-02, 公開日: 2013-03-27, 最終更新日: 2024-02-28)

• 主引用文献: Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T.; Structures of branched-chain alpha-ketoacid dehydrogenase kinase-inhibitor complexes; To be Published,

実験手法

X-RAY DIFFRACTION (1.97 Å)