4DYM

Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135

4DYM の概要

• エントリーDOI: 10.2210/pdb4dym/pdb
• 関連するPDBエントリー: 3MTF 3OOM
• 分子名称: Activin receptor type-1, SULFATE ION, 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, ... (5 entities in total)
• 機能のキーワード: structural genomics, structural genomics consortium, sgc, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: Q04771
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35398.49

構造登録者

Chaikuad, A.,Sanvitale, C.,Cooper, C.,Canning, P.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Krojer, T.,Filippakopoulos, P.,Muniz, J.R.C.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (登録日: 2012-02-29, 公開日: 2012-03-21, 最終更新日: 2023-09-13)

• 主引用文献: Chaikuad, A.,Sanvitale, C.,Cooper, C.,Canning, P.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Krojer, T.,Filippakopoulos, P.,Muniz, J.R.C.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC); Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135; To be Published,

実験手法

X-RAY DIFFRACTION (2.42 Å)