4DW6
Novel N-phenyl-phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High-Throughput Synthesis.
4DW6 の概要
エントリーDOI | 10.2210/pdb4dw6/pdb |
分子名称 | HTH-type transcriptional regulator EthR, N-[4-(1,3-benzothiazol-2-yl)phenyl]-2-(3-methoxyphenoxy)acetamide, AMMONIUM ION, ... (5 entities in total) |
機能のキーワード | tetr-family, transcritptional regulatory repressor, inhibitor, dna binding protein, transcription repressor-inhibitor complex, transcription-inhibitor complex, transcription/inhibitor |
由来する生物種 | Mycobacterium tuberculosis |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 26637.85 |
構造登録者 | Flipo, M.,Willand, N.,Lecat-Guillet, N.,Hounsou, C.,Desroses, M.,Leroux, F.,Lens, Z.,Villeret, V.,Wohlkonig, A.,Wintjens, R.,Christophe, T.,Jeon, H.K.,Locht, C.,Brodin, P.,Baulard, A.R.,Deprez, B. (登録日: 2012-02-24, 公開日: 2013-03-27, 最終更新日: 2024-02-28) |
主引用文献 | Flipo, M.,Willand, N.,Lecat-Guillet, N.,Hounsou, C.,Desroses, M.,Leroux, F.,Lens, Z.,Villeret, V.,Wohlkonig, A.,Wintjens, R.,Christophe, T.,Kyoung Jeon, H.,Locht, C.,Brodin, P.,Baulard, A.R.,Deprez, B. Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. J.Med.Chem., 55:6391-6402, 2012 Cited by PubMed: 22738293DOI: 10.1021/jm300377g 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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