4DU0

Crystal structure of human alpha-defensin 1, HNP1 (G17A mutant)

Summary for 4DU0

Entry DOI	10.2210/pdb4du0/pdb
Related	3GNY 3HJ2 3HJD
Descriptor	Neutrophil defensin 1, GLYCEROL, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	cysteine rich antimicrobial peptide, alpha-defensin, hnp1, human alpha-defensin 1, g17a mutant, defensin fold, antimicrobial peptide, human neutrophils, antibiotic
Biological source	Homo sapiens (human)
Cellular location	Secreted: P59665
Total number of polymer chains	4
Total formula weight	14303.83
Authors	Wu, X.,Lu, W.,Pazgier, M. (deposition date: 2012-02-21, release date: 2012-04-11, Last modification date: 2023-09-13)
Primary citation	Zhao, L.,Ericksen, B.,Wu, X.,Zhan, C.,Yuan, W.,Li, X.,Pazgier, M.,Lu, W. Invariant gly residue is important for alpha-defensin folding, dimerization, and function: a case study of the human neutrophil alpha-defensin HNP1 J.Biol.Chem., 287:18900-18912, 2012 Cited by PubMed: 22496447 DOI: 10.1074/jbc.M112.355255 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation