4DPH

Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH

4DPH の概要

• エントリーDOI: 10.2210/pdb4dph/pdb
• 関連するPDBエントリー: 1J3K 2JSU 3QG2 4DDR 4DP3 4DPD
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase, 2,4-diamino-6-methyl-5-[3-(2,4,5-trichlorophenoxy)propyloxy]pyrimidine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
• 機能のキーワード: plasmodium falciparum, antifolate, rossmann fold, reductase, nadph binding, oxidoreductase, transferase
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 146564.89

構造登録者

Yuthavong, Y.,Vilaivan, T.,Kamchonwongpaisan, S.,Charman, S.A.,McLennan, D.N.,White, K.L.,Vivas, L.,Bongard, E.,Chitnumsub, P.,Tarnchompoo, B.,Thongphanchang, C.,Taweechai, S.,Vanichtanakul, J.,Arwon, U.,Fantauzzi, P.,Yuvaniyama, J.,Charman, W.N.,Matthews, D. (登録日: 2012-02-13, 公開日: 2012-11-14, 最終更新日: 2023-11-08)

• 主引用文献: Yuthavong, Y.,Tarnchompoo, B.,Vilaivan, T.,Chitnumsub, P.,Kamchonwongpaisan, S.,Charman, S.A.,McLennan, D.N.,White, K.L.,Vivas, L.,Bongard, E.,Thongphanchang, C.,Taweechai, S.,Vanichtanankul, J.,Rattanajak, R.,Arwon, U.,Fantauzzi, P.,Yuvaniyama, J.,Charman, W.N.,Matthews, D.; Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target; Proc.Natl.Acad.Sci.USA, 109:16823-16828, 2012; PubMed: 23035243; DOI: 10.1073/pnas.1204556109

実験手法

X-RAY DIFFRACTION (2.38 Å)