4DMY
Cathepsin K inhibitor
Summary for 4DMY
Entry DOI | 10.2210/pdb4dmy/pdb |
Related | 4DMX |
Descriptor | Cathepsin K, (1R,2R)-N-(1-cyanocyclopropyl)-2-[(8-fluoro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]cyclohexanecarboxamide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | cathepsin k inhibitor, osteoarthritis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 2 |
Total formula weight | 48340.24 |
Authors | Dossetter, A.G.,Beeley, H.,Bowyer, J.,Cook, C.R.,Crawford, J.J.,Finlayson, J.E.,Heron, N.M.,Heyes, C.,Highton, A.J.,Hudson, J.A.,Kenny, P.W.,Martin, S.,MacFaul, P.A.,McGuire, T.M.,Gutierrez, P.M.,Morley, A.D.,Morris, J.J.,Page, K.M.,Rosenbrier Ribeiro, L.,Sawney, H.,Steinbacher, S.,Krapp, S.,Jestel, A.,Smith, C.,Vickers, M. (deposition date: 2012-02-08, release date: 2012-07-11, Last modification date: 2018-01-24) |
Primary citation | Dossetter, A.G.,Beeley, H.,Bowyer, J.,Cook, C.R.,Crawford, J.J.,Finlayson, J.E.,Heron, N.M.,Heyes, C.,Highton, A.J.,Hudson, J.A.,Jestel, A.,Kenny, P.W.,Krapp, S.,Martin, S.,MacFaul, P.A.,McGuire, T.M.,Gutierrez, P.M.,Morley, A.D.,Morris, J.J.,Page, K.M.,Ribeiro, L.R.,Sawney, H.,Steinbacher, S.,Smith, C.,Vickers, M. (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis. J.Med.Chem., 55:6363-6374, 2012 Cited by PubMed: 22742641DOI: 10.1021/jm3007257 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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