4DGP
The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2)
Summary for 4DGP
Entry DOI | 10.2210/pdb4dgp/pdb |
Related | 4DGX |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11 (2 entities in total) |
Functional Keywords | hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q06124 |
Total number of polymer chains | 1 |
Total formula weight | 61761.64 |
Authors | Yu, Z.H.,Xu, J.,Walls, C.D.,Chen, L.,Zhang, S.,Wu, L.,Wang, L.N.,Liu, S.J.,Zhang, Z.Y. (deposition date: 2012-01-26, release date: 2013-03-06, Last modification date: 2024-02-28) |
Primary citation | Yu, Z.H.,Xu, J.,Walls, C.D.,Chen, L.,Zhang, S.,Zhang, R.,Wu, L.,Wang, L.,Liu, S.,Zhang, Z.Y. Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288:10472-10482, 2013 Cited by PubMed: 23457302DOI: 10.1074/jbc.M113.450023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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