4DDR

Human dihydrofolate reductase complexed with NADPH and P218

4DDR の概要

• エントリーDOI: 10.2210/pdb4ddr/pdb
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, ... (4 entities in total)
• 機能のキーワード: antifolate, nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22455.35

構造登録者

Yuthavong, Y.,Tarnchompoo, B.,Vilaivan, T.,Chitnumsub, P.,Kamchonwongpaisan, S.,Charman, S.A.,McLennan, D.N.,White, K.L.,Vivas, L.,Bongard, E.,Thongphanchang, C.,Taweechai, S.,Vanichtanankul, J.,Rattanajak, R.,Arwon, U.,Fantauzzi, P.,Yuvaniyama, J.,Charman, W.N.,Matthews, D. (登録日: 2012-01-19, 公開日: 2012-11-14, 最終更新日: 2023-11-08)

• 主引用文献: Yuthavong, Y.,Tarnchompoo, B.,Vilaivan, T.,Chitnumsub, P.,Kamchonwongpaisan, S.,Charman, S.A.,McLennan, D.N.,White, K.L.,Vivas, L.,Bongard, E.,Thongphanchang, C.,Taweechai, S.,Vanichtanankul, J.,Rattanajak, R.,Arwon, U.,Fantauzzi, P.,Yuvaniyama, J.,Charman, W.N.,Matthews, D.; Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target; Proc.Natl.Acad.Sci.USA, 109:16823-16828, 2012; PubMed: 23035243; DOI: 10.1073/pnas.1204556109

実験手法

X-RAY DIFFRACTION (2.05 Å)