4DC1

Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH

Summary for 4DC1

Related4DBZ 4DC0
DescriptorKetoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
Functional Keywordsrossmann fold, short-chain dehydrogenase/reductase, ketoreductase, oxidoreductase
Biological sourceStreptomyces coelicolor
Total number of polymer chains2
Total molecular weight60387.57
Authors
Javidpour, P.,Tsai, S.-C. (deposition date: 2012-01-16, release date: 2013-01-16, Last modification date: 2013-11-27)
Primary citation
Javidpour, P.,Bruegger, J.,Srithahan, S.,Korman, T.P.,Crump, M.P.,Crosby, J.,Burkart, M.D.,Tsai, S.C.
The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.
Chem.Biol., 20:1225-1234, 2013
PubMed: 24035284 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2013.07.016
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.82 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.253100.2%9.8%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution