4DBW
Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 2'-desmethyl-indomethacin
4DBW の概要
エントリーDOI | 10.2210/pdb4dbw/pdb |
分子名称 | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl]acetic acid, ... (4 entities in total) |
機能のキーワード | castrate resistant prostate cancer, akr1c3 selective inhibitor, tim barrel, steroid metabolism, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: P42330 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 76654.28 |
構造登録者 | Chen, M.,Christianson, D.W.,Marnett, L.J.,Penning, T.M. (登録日: 2012-01-16, 公開日: 2013-03-06, 最終更新日: 2023-09-13) |
主引用文献 | Liedtke, A.J.,Adeniji, A.O.,Chen, M.,Byrns, M.C.,Jin, Y.,Christianson, D.W.,Marnett, L.J.,Penning, T.M. Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17 beta-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. J.Med.Chem., 56:2429-2446, 2013 Cited by PubMed: 23432095DOI: 10.1021/jm3017656 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.802 Å) |
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