4D44

Crystal structure of S. aureus FabI in complex with NADP and 5-ethyl- 4-fluoro-2-((2-fluoropyridin-3-yl)oxy)phenol

4D44 の概要

• エントリーDOI: 10.2210/pdb4d44/pdb
• 関連するPDBエントリー: 4D41 4D42 4D43 4D45 4D46
• 分子名称: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, safabi, fabi
• 由来する生物種: STAPHYLOCOCCUS AUREUS SUBSP. AUREUS N315
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 258939.16

構造登録者

Schiebel, J.,Chang, A.,Tonge, P.J.,Sotriffer, C.A.,Kisker, C. (登録日: 2014-10-26, 公開日: 2015-03-04, 最終更新日: 2023-12-20)

• 主引用文献: Schiebel, J.,Chang, A.,Merget, B.,Bommineni, G.R.,Yu, W.,Spagnuolo, L.A.,Baxter, M.V.,Tareilus, M.,Tonge, P.J.,Kisker, C.,Sotriffer, C.A.; An Ordered Water Channel in Staphylococcus Aureus Fabi: Unraveling the Mechanism of Substrate Recognition and Reduction.; Biochemistry, 54:1943-, 2015; PubMed: 25706582; DOI: 10.1021/BI5014358

実験手法

X-RAY DIFFRACTION (1.8 Å)