4D43

Crystal structure of S. aureus FabI in complex with NADP and 2-(2- chloro-4-nitrophenoxy)-5-ethyl-4-fluorophenol

4D43 の概要

• エントリーDOI: 10.2210/pdb4d43/pdb
• 関連するPDBエントリー: 4D41 4D42 4D44 4D45 4D46
• 分子名称: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (6 entities in total)
• 機能のキーワード: short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, safabi, fabi, oxidoreductase
• 由来する生物種: STAPHYLOCOCCUS AUREUS SUBSP. AUREUS N315
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 259541.04

構造登録者

Schiebel, J.,Chang, A.,Tonge, P.J.,Sotriffer, C.A.,Kisker, C. (登録日: 2014-10-26, 公開日: 2015-03-04, 最終更新日: 2023-12-20)

• 主引用文献: Schiebel, J.,Chang, A.,Merget, B.,Bommineni, G.R.,Yu, W.,Spagnuolo, L.A.,Baxter, M.V.,Tareilus, M.,Tonge, P.J.,Kisker, C.,Sotriffer, C.A.; An Ordered Water Channel in Staphylococcus Aureus Fabi: Unraveling the Mechanism of Substrate Recognition and Reduction.; Biochemistry, 54:1943-, 2015; PubMed: 25706582; DOI: 10.1021/BI5014358

実験手法

X-RAY DIFFRACTION (2.15 Å)